Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 9/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20449623 | 0.94 | TMEM97 (0.42) | PDK1PDK2PDK3PDK4KDM1A | |
| SCHEMBL2708318 | 0.89 | TMEM97 (0.41) | PDK1PDK2PDK3PDK4TMEM97 | |
| SCHEMBL26984159 | 0.84 | KDM1A (0.48) | PDK1PDK2PDK3PDK4KDM1A | |
| SCHEMBL28680130 | 0.84 | KDM1A (0.48) | PDK1PDK2PDK3PDK4KDM1A | |
| SCHEMBL27129689 | 0.83 | SIGMAR1 (0.47) | KDM1ATMEM97SIGMAR1SMN1; SMN2NPC1 | |
| SCHEMBL26984268 | 0.83 | SIGMAR1 (0.47) | KDM1ATMEM97SIGMAR1SMN1; SMN2NPC1 | |
| SCHEMBL22473262 | 0.82 | ADAM10 (0.47) | KDM1ATMEM97SIGMAR1SMN1; SMN2NPC1 | |
| SCHEMBL26984155 | 0.82 | ADAM10 (0.47) | KDM1ATMEM97SIGMAR1SMN1; SMN2NPC1 | |
| SCHEMBL3736894 | 0.82 | TMEM97 (0.44) | KDM1ATMEM97SIGMAR1SMN1; SMN2NPC1 | |
| SCHEMBL27128343 | 0.82 | KDM1A (0.47) | PDK1PDK2PDK3PDK4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0828754-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038471-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1996-12-05 | — | — | WO | disclosed |