Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.42 |
| ▸ | PRNP | P04156 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161591 | 0.89 | CA12 (0.45) | CA12CA1CA2CA7CA13 | |
| SCHEMBL6164220 | 0.82 | CA12 (0.52) | CA12CA1CA2CA7CA13 | |
| SCHEMBL15700553 | 0.78 | CA12 (0.62) | CA12CA1CA2CA7CA13 | |
| SCHEMBL17722534 | 0.77 | CA12 (0.60) | CA12CA1CA2CA7CA13 | |
| SCHEMBL17718486 | 0.73 | CA12 (0.55) | CA12CA1CA2CA7CA13 | |
| SCHEMBL6166121 | 0.73 | MEN1 (0.46) | ALDH1A1HSD17B10TSHRLMNAKMT2A | |
| SCHEMBL15647448 | 0.72 | CA13 (1.00) | CA12CA1CA2CA7CA13 | |
| SCHEMBL18655822 | 0.69 | MEN1 (0.36) | KMT2AHTT | |
| SCHEMBL6164956 | 0.69 | KIF11 (0.37) | CA12CA1CA2CA7CA13 | |
| SCHEMBL7023976 | 0.68 | SMN1; SMN2 (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934310-B1 | THIO ACID DERIVED MONOCYCLIC N-HETEROCYCLICS AS ANTICOAGULANTS | SCHERING AG (DE) | 2005-02-09 | — | — | EP | disclosed |
| US-6221886-B1 | Thio acid derived monocyclic N-heterocyclics as anticoagulants | BERLEX LABORATORIES, INC. | 2001-04-24 | — | — | US | disclosed |
| US-6166014-A | Thio acid derived monocyclic N-heterocyclics as anticoagulants | BERLEX LABORATORIES, INC. (US) | 2000-12-26 | — | — | US | disclosed |
| US-6162807-A | Thio acid derived monocyclic N-heterocyclics as anticoagulants | BERLEX LABORATORIES, INC. (US) | 2000-12-19 | — | — | US | disclosed |
| US-6150382-A | ENZYME INHIBITORS OF BLOOD COAGULATION FACTOR XA, A SERINE PROTEASE CLASS OF ENZYMES; E.G., 4-HYDROXY-3-((4-(2-CARBOXY-METHYL)THIO-6-(3-(1-METHYL)-6-(3-(1 -METHYL)IMIDAZOLIN-2-YL)-PHENOXY-3,5-DIFLUOROPYRIDINE AND DERIVATIVES | BERLEX LABORATORIES, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6034084-A | CARDIOVASCULAR DISORDERS | BERLEX LABORATORIES, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-6004985-A | BLOOD-COAGULATION FACTOR XA INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0934310-A1 | THIO ACID DERIVED MONOCYCLIC $i(N)-HETEROCYCLICS AS ANTICOAGULANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015547-A1 | THIO ACID DERIVED MONOCYCLIC N-HETEROCYCLICS AS ANTICOAGULANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-04-16 | — | — | WO | disclosed |