SCHEMBL6161591

SCHEMBL6161591

O=C(O)CCCSc1c(F)c(F)nc(F)c1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.45
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA7 P43166 2/20 0.45
CA13 Q8N1Q1 2/20 0.45
ALDH1A1 P00352 2/20 0.44
CSNK2A2 P19784 2/20 0.40
CSNK2A1 P68400 2/20 0.40
CXCR1 P25024 1/20 0.37
CXCR2 P25025 1/20 0.37
TSHR P16473 2/20 0.37
FFAR4 Q5NUL3 3/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2E1 P05181 1/20 0.35
CYP2C8 P10632 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2B6 P20813 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6161347 0.89 CA12 (0.56) CA12CA1CA2CA7CA13
SCHEMBL6166121 0.80 MEN1 (0.46) ALDH1A1CXCR1CXCR2TSHRLMNA
SCHEMBL6164220 0.79 CA12 (0.52) CA12CA1CA2CA7CA13
SCHEMBL14252013 0.69 CA12 (0.43) CA12CA1CA2CA7CA13
SCHEMBL15700553 0.68 CA12 (0.62) CA12CA1CA2CA7CA13
SCHEMBL17722534 0.67 CA12 (0.60) CA12CA1CA2CA7CA13
SCHEMBL6164956 0.67 KIF11 (0.37) CA12CA1CA2CA7CA13
SCHEMBL7023976 0.66 SMN1; SMN2 (0.33) SMN1; SMN2
SCHEMBL414504 0.66 ALDH1A1 (0.70) ALDH1A1CXCR1CXCR2TSHRFFAR4
SCHEMBL756105 0.61 TSHR (0.71) ALDH1A1TSHRFFAR4CYP1A2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934310-B1 THIO ACID DERIVED MONOCYCLIC N-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AG (DE) 2005-02-09 EP disclosed
US-6221886-B1 Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. 2001-04-24 US disclosed
US-6166014-A Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. (US) 2000-12-26 US disclosed
US-6162807-A Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. (US) 2000-12-19 US disclosed
US-6150382-A ENZYME INHIBITORS OF BLOOD COAGULATION FACTOR XA, A SERINE PROTEASE CLASS OF ENZYMES; E.G., 4-HYDROXY-3-((4-(2-CARBOXY-METHYL)THIO-6-(3-(1-METHYL)-6-(3-(1 -METHYL)IMIDAZOLIN-2-YL)-PHENOXY-3,5-DIFLUOROPYRIDINE AND DERIVATIVES BERLEX LABORATORIES, INC. (US) 2000-11-21 US disclosed
US-6034084-A CARDIOVASCULAR DISORDERS BERLEX LABORATORIES, INC. (US) 2000-03-07 US disclosed
US-6004985-A BLOOD-COAGULATION FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. (US) 1999-12-21 US disclosed
EP-0934310-A1 THIO ACID DERIVED MONOCYCLIC $i(N)-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AKTIENGESELLSCHAFT (DE) 1999-08-11 EP disclosed
WO-1998015547-A1 THIO ACID DERIVED MONOCYCLIC N-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AKTIENGESELLSCHAFT (DE) 1998-04-16 WO disclosed