Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159342 | 0.80 | CASP1 (0.60) | CASP1 | |
| SCHEMBL2449106 | 0.72 | KMT2A (0.60) | SMN1; SMN2KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL2449111 | 0.72 | KMT2A (0.60) | SMN1; SMN2KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL14401163 | 0.69 | ECE1 (0.44) | CASP1SMN1; SMN2MMP2MMP9KMT2A | |
| SCHEMBL16203198 | 0.68 | ECE1 (0.44) | CASP1ALDH1A1ECE1 | |
| SCHEMBL6158236 | 0.68 | KMT2A (0.68) | CASP1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL27561937 | 0.68 | KMT2A (0.68) | CASP1RAB9ASMN1; SMN2NPC1KMT2A | |
| Propionic Acid SCHEMBL11833224 | 0.68 | FFAR3 (0.46) | RAB9ASMN1; SMN2KMT2APOLB | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL6353320 | 0.67 | FFAR1 (0.37) | SMN1; SMN2POLB | |
| SCHEMBL6160049 | 0.67 | CASP1 (0.66) | CASP1KDM4ERAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1082127-A4 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1082127-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999056765-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-11-11 | — | — | WO | disclosed |