Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 13/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.56 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6161381 | 0.99 | PTGIR (0.57) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL6159356 | 0.88 | ADRA2A (0.50) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| Hydrochloric Acid SCHEMBL6161371 | 0.87 | ADRA2A (0.49) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL5658067 | 0.85 | WDR5 (0.60) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL6160627 | 0.83 | ADRA2A (0.52) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL6158402 | 0.83 | PTGIR (0.63) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| Hydrochloric Acid SCHEMBL6161625 | 0.81 | ADRA2A (0.49) | PTGIRADRA2AADRA2BADRA2CWDR5 | |
| SCHEMBL6159168 | 0.80 | ADRA2A (0.48) | PTGIRADRA2AADRA2BADRA2CGPR65 | |
| SCHEMBL6159740 | 0.80 | ADRA2A (0.50) | PTGIRADRA2AADRA2BADRA2CAOC3 | |
| SCHEMBL6056621 | 0.79 | ADRA2A (0.45) | PTGIRADRA2AADRA2BADRA2CAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339694-B1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-09-21 | — | — | EP | disclosed |
| EP-1339694-A1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-03 | — | — | EP | disclosed |
| US-6417186-B1 | TREATING PAIN, URINARY TRACT INFECTIONS, INFLAMMATION, RESPIRATORY DISEASE STATES FROM ALLERGIES OR ASTHMA, EDEMA FORMATION OR HYPOTENSIVE VASCULAR DISEASES. | SYNTEX (U.S.A.) LLC | 2002-07-09 | — | — | US | disclosed |
| WO-2002040453-A1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-23 | — | — | WO | disclosed |