SCHEMBL6161737

SCHEMBL6161737

OCCOCCC1CCCN1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.39
MAPK1 P28482 1/20 0.39
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
CHRNB4 P30926 3/20 0.33
CHRNA3 P32297 3/20 0.33
FDPS P14324 2/20 0.33
HRH3 Q9Y5N1 1/20 0.32
CYP2D6 P10635 2/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
TP53 P04637 1/20 0.32
CYP1A2 P05177 1/20 0.32
MLNR O43193 1/20 0.32
ABCB11 O95342 1/20 0.32
EGFR P00533 1/20 0.32
FYN P06241 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
HTR1A P08908 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10626116 0.94 FDPS (0.39) TSHRMAPK1MEN1KMT2AFDPS
SCHEMBL12371288 0.90 CYP2D6 (0.36) TSHRMEN1KMT2ACHRNB4CHRNA3
SCHEMBL593510 0.79 CHRNA3 (0.37) CHRNB4CHRNA3FDPSHRH3
SCHEMBL593996 0.79 CHRNA3 (0.37) CHRNB4CHRNA3FDPSHRH3
SCHEMBL197631 0.79
SCHEMBL2908604 0.79 FDPS (0.38) TSHRMEN1KMT2ACHRNB4CHRNA3
SCHEMBL5696915 0.79
SCHEMBL1190914 0.79
SCHEMBL12471863 0.78 HRH3 (0.36) TSHRMEN1KMT2ACHRNB4CHRNA3
SCHEMBL592511 0.78 TSHR (0.36) TSHRCHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9988483-B2 Pyrrolidine-based catalysts for use in polyurethane materials HUNTSMAN PETROCHEMICAL LLC (US) 2018-06-05 US claimed
EP-3161029-A1 PYRROLIDINE-BASED CATALYSTS FOR USE IN POLYURETHANE MATERIALS Huntsman Petrochemical LLC (US) 2017-05-03 EP claimed
US-20170101501-A1 PYRROLIDINE-BASED CATALYSTS FOR USE IN POLYURETHANE MATERIALS HUNTSMAN PETROCHEMICAL LLC 2017-04-13 US claimed
WO-2015200408-A1 PYRROLIDINE-BASED CATALYSTS FOR USE IN POLYURETHANE MATERIALS HUNTSMAN PETROCHEMICAL LLC (US) 2015-12-30 WO claimed
US-9988483-B2 Pyrrolidine-based catalysts for use in polyurethane materials HUNTSMAN PETROCHEMICAL LLC (US) 2018-06-05 US disclosed
US-20170101501-A1 PYRROLIDINE-BASED CATALYSTS FOR USE IN POLYURETHANE MATERIALS HUNTSMAN PETROCHEMICAL LLC 2017-04-13 US disclosed
EP-1575943-A1 3-CYANO-QUINOLINE DERIVATIVES AstraZeneca AB (SE) 2005-09-21 EP disclosed
EP-1528925-A1 QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER Astrazeneca AB (SE) 2005-05-11 EP disclosed
EP-1521751-A1 SUBSTITUTED 3-CYANOQUINOLINES AS MEK INHIBITORS Astrazeneca AB (SE) 2005-04-13 EP disclosed
WO-2004041811-A1 3-CYANO-QUINOLINE DERIVATIVES ASTRAZENECA AB (SE) 2004-05-21 WO disclosed
WO-2004004732-A1 QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2004-01-15 WO disclosed
WO-2004005284-A1 SUBSTITUTED 3-CYANOQUINOLINES AS MEK INHIBITORS ASTRAZENECA AB (SE) 2004-01-15 WO disclosed
US-4767767-A ANALGESIC, ANTIINFLAMMATORY AGENT FERRER INTERNACIONAL S.A. (ES) 1988-08-30 US disclosed
EP-0094065-A2 2-Aminobenzoic acid derivatives, a process for their preparation and pharmaceutical compositions FERRER INTERNACIONAL, S.A. (ES) 1983-11-16 EP disclosed