Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522189 | 0.79 | KDM4E (0.38) | KDM4ESYKALDH1A1TSHR | |
| SCHEMBL8202032 | 0.77 | KDM4E (0.34) | KDM4EALDH1A1TSHR | |
| SCHEMBL3160945 | 0.68 | KDM4E (0.35) | KDM4ESYKALDH1A1TSHR | |
| SCHEMBL27530318 | 0.68 | KDM4E (0.35) | KDM4EALDH1A1TSHR | |
| SCHEMBL1174120 | 0.68 | DPP4 (0.45) | SYKGPR142 | |
| SCHEMBL6242818 | 0.68 | DPP4 (0.45) | SYKGPR142 | |
| SCHEMBL1174119 | 0.68 | DPP4 (0.45) | SYKGPR142 | |
| SCHEMBL27342600 | 0.68 | KDM4E (0.36) | KDM4E | |
| SCHEMBL3842916 | 0.67 | KDM4E (0.34) | KDM4EALDH1A1TSHR | |
| SCHEMBL907621 | 0.66 | KDM4E (0.44) | KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |