Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 7/20 | 0.44 |
| ▸ | FNTB | P49356 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1538260 | 0.87 | FNTA (0.56) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL30419724 | 0.87 | FNTA (0.56) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL6866186 | 0.85 | FNTA (0.47) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL5516658 | 0.85 | HSD17B10 (0.57) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL5722628 | 0.84 | FNTA (0.46) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL1644048 | 0.84 | FNTA (0.48) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL5509068 | 0.82 | MAPT (0.46) | FNTAFNTBHSD17B10CYP3A4MAPT | |
| SCHEMBL13573663 | 0.82 | FNTA (0.47) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL5657960 | 0.80 | FNTA (0.48) | FNTAFNTBHSD17B10ALDH1A1GLA | |
| SCHEMBL6862062 | 0.79 | FNTA (0.43) | FNTAFNTBHSD17B10CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107962-B1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6495564-B1 | SUCH AS 3-(6-((4-CHLORO-PHENYL)-HYDROXY-(3-METHYL-3H-IMIDAZOL-4-YL)-METHYL)-1-METHYL-2-OXO-1,2-DIHYDRO-QUINOLIN-4-YL)-BENZALDEHYDE O-METHYL-OXIME; INHIBITING ABNORMAL CELL GROWTH | PFIZER INC. | 2002-12-17 | — | — | US | disclosed |
| EP-1107962-A1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012498-A1 | QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-03-09 | — | — | WO | disclosed |