Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.61 |
| ▸ | RAF1 | P04049 | 2/20 | 0.51 |
| ▸ | HCK | P08631 | 2/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162634 | 0.87 | MAPK14 (0.58) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6166487 | 0.85 | MAPK14 (0.60) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6167100 | 0.80 | RAF1 (0.57) | MAPK14RAF1MAPK12 | |
| SCHEMBL6163825 | 0.80 | MAPK14 (0.51) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6163426 | 0.77 | MAPK14 (0.59) | MAPK14RAF1MAPK12TNFBRAF | |
| SCHEMBL6160912 | 0.77 | MAPK14 (0.56) | MAPK14HCKMAPK12TNF | |
| SCHEMBL3241506 | 0.76 | MAPK14 (1.00) | MAPK14RAF1ALDH1A1MEN1MAPT | |
| SCHEMBL6161474 | 0.76 | MAPK14 (0.63) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6162480 | 0.75 | MAPK14 (0.59) | MAPK14HCKMAPK12TNFBRAF | |
| SCHEMBL7830130 | 0.75 | MAPK14 (0.56) | MAPK14RAF1HCKMAPK12TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |