Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.63 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162480 | 0.85 | MAPK14 (0.59) | MAPK14TNFHCKMAPK12 | |
| SCHEMBL6160912 | 0.83 | MAPK14 (0.56) | MAPK14TNFHCKMAPK12 | |
| SCHEMBL6161478 | 0.81 | MAPK14 (0.61) | MAPK14RAF1 | |
| SCHEMBL6165058 | 0.79 | MAPK14 (0.55) | MAPK14CCR8FLT1KDRALDH1A1 | |
| SCHEMBL3242741 | 0.78 | MAPK14 (1.00) | MAPK14RAF1MAPK12 | |
| SCHEMBL6162316 | 0.76 | MAPK14 (0.61) | MAPK14ALDH1A1RAF1TNFHCK | |
| SCHEMBL6166487 | 0.75 | MAPK14 (0.60) | MAPK14RAF1TNFHCKMAPK12 | |
| SCHEMBL6162634 | 0.74 | MAPK14 (0.58) | MAPK14RAF1TNFHCKMAPK12 | |
| SCHEMBL6162921 | 0.73 | MAPK14 (0.56) | MAPK14TNFHCKMAPK12 | |
| SCHEMBL6163413 | 0.72 | MAPK14 (0.53) | MAPK14CCR8FLT1KDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |