Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.60 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | HCK | P08631 | 9/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162634 | 0.91 | MAPK14 (0.58) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6162480 | 0.90 | MAPK14 (0.59) | MAPK14HCKMAPK12TNFSRC | |
| SCHEMBL6162316 | 0.85 | MAPK14 (0.61) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6161327 | 0.81 | MAPK14 (0.61) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL7830130 | 0.81 | MAPK14 (0.56) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6160912 | 0.81 | MAPK14 (0.56) | MAPK14HCKMAPK12TNF | |
| SCHEMBL6164164 | 0.81 | MAPK14 (0.58) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL7665705 | 0.80 | MAPK14 (0.50) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6163117 | 0.80 | RAF1 (0.56) | MAPK14RAF1MAPK12 | |
| SCHEMBL6162950 | 0.79 | MAPK14 (0.46) | MAPK14RAF1HCKMAPK12TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | claimed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | claimed |
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| EP-1163236-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |
| WO-2000055152-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |