Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160893 | 0.80 | HTR6 (0.37) | HTR6MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL6160345 | 0.80 | NR3C1 (0.37) | MAPK11MAPK14MAPK13MAPK12LSS | |
| SCHEMBL6159161 | 0.79 | KCNH2 (0.38) | MAPK11MAPK14MAPK13MAPK12LSS | |
| SCHEMBL6163249 | 0.74 | GCGR (0.40) | MAPK11MAPK14MAPK13MAPK12LSS | |
| SCHEMBL6166497 | 0.73 | MAPK11 (0.40) | HTR6MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5216464 | 0.72 | MAPK11 (0.43) | HTR6MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL6164467 | 0.67 | RIPK3 (0.40) | MAPK11MAPK14LSSCHRM1CHRM2 | |
| SCHEMBL6166494 | 0.66 | MAPK11 (0.38) | HTR6MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL6162461 | 0.61 | MAPK14 (0.47) | MAPK11MAPK14MAPK13MAPK12LSS | |
| SCHEMBL5459338 | 0.60 | MAPK11 (0.53) | MAPK11MAPK14MAPK13MAPK12MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542680-A1 | 1, 4, 5-SUBSTITUTED 1, 2-DIHYDRO-PYRAZOL-3-ONE AND 3-ALKOXY-1H-PYRAZOLE DERIVATIVES S TNF-ALPHA AND INTERLEUKIN LOWERING AGENTS FOR THE TREATMENT OF INFLAMMATIONS | Amgen Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004022055-A1 | 1, 4, 5-SUBSTITUTED 1, 2-DIHYDRO-PYRAZOL-3-ONE AND 3-ALKOXY-1H-PYRAZOLE DERIVATIVES S TNF-ALPHA AND INTERLEUKIN LOWERING AGENTS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2004-03-18 | — | — | WO | disclosed |