Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162521 | 0.91 | KDR (0.63) | PDGFRBFGFR1KDRNPC1RAB9A | |
| SCHEMBL6157685 | 0.86 | PDGFRB (0.69) | PDGFRBFGFR1KDRNPC1RAB9A | |
| SCHEMBL12834035 | 0.83 | KDM4E (0.73) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL14091475 | 0.82 | KDM4E (0.55) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL22955685 | 0.81 | HDAC6 (0.54) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL14091584 | 0.80 | KDM4E (0.55) | FGFR1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL2617479 | 0.79 | KDM4E (0.71) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL6159118 | 0.79 | KDR (0.74) | PDGFRBFGFR1KDRNPC1RAB9A | |
| SCHEMBL14090368 | 0.79 | F2 (0.69) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL3503147 | 0.79 | KDR (1.00) | PDGFRBFGFR1KDRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226119-B1 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2005-03-16 | — | — | EP | disclosed |
| US-6479512-B1 | TO TREAT TYROSINE KINASE-DEPENDENT DISEASES AND CONDITIONS, SUCH AS ANGIOGENESIS, CANCER, TUMOR GROWTH, ATHEROSCLEROSIS, AGE RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY, INFLAMMATORY DISEASES, ETC. | MERCK & CO., INC. | 2002-11-12 | — | — | US | disclosed |