Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | TP53 | P04637 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157677 | 0.90 | KDR (0.69) | PDGFRBFGFR1KDRTDP1MAPT | |
| SCHEMBL6162528 | 0.86 | PDGFRB (0.63) | PDGFRBFGFR1KDRTDP1MAPT | |
| SCHEMBL3503147 | 0.82 | KDR (1.00) | PDGFRBFGFR1KDRMAPTTP53 | |
| SCHEMBL6158996 | 0.81 | KDR (0.74) | PDGFRBFGFR1KDRTDP1MAPT | |
| SCHEMBL6159118 | 0.81 | KDR (0.74) | PDGFRBFGFR1KDRMAPTTP53 | |
| SCHEMBL3169656 | 0.80 | TDP1 (0.60) | TDP1MAPTTP53POLBL3MBTL1 | |
| SCHEMBL3178116 | 0.78 | CHEK2 (0.78) | NPC1RAB9AKMT2ACHEK2NR4A2 | |
| SCHEMBL6333156 | 0.78 | KDR (0.70) | PDGFRBFGFR1KDRMAPTNPC1 | |
| SCHEMBL3162699 | 0.78 | NR4A2 (0.64) | TDP1MAPTTP53POLBL3MBTL1 | |
| SCHEMBL3171782 | 0.78 | RAB9A (0.65) | TDP1MAPTTP53POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226119-B1 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2005-03-16 | — | — | EP | claimed |
| US-6479512-B1 | TO TREAT TYROSINE KINASE-DEPENDENT DISEASES AND CONDITIONS, SUCH AS ANGIOGENESIS, CANCER, TUMOR GROWTH, ATHEROSCLEROSIS, AGE RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY, INFLAMMATORY DISEASES, ETC. | MERCK & CO., INC. | 2002-11-12 | — | — | US | claimed |
| EP-1226119-B1 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2005-03-16 | — | — | EP | disclosed |
| US-6479512-B1 | TO TREAT TYROSINE KINASE-DEPENDENT DISEASES AND CONDITIONS, SUCH AS ANGIOGENESIS, CANCER, TUMOR GROWTH, ATHEROSCLEROSIS, AGE RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY, INFLAMMATORY DISEASES, ETC. | MERCK & CO., INC. | 2002-11-12 | — | — | US | disclosed |