Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.77 |
| ▸ | F3 | P13726 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NHERF1 | O14745 | 3/20 | 0.55 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | PYGL | P06737 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Chloroindole-2-Carboxylic Acid SCHEMBL720582 | 0.88 | F7 (1.00) | F7F3MEN1NPC1RAB9A | |
| 5-Chloroindole-2-Carboxylic Acid SCHEMBL6921825 | 0.86 | F7 (0.96) | F7F3MEN1NPC1RAB9A | |
| 5-Chloroindole-2-Carboxylic Acid SCHEMBL27410586 | 0.82 | F7 (0.82) | F7F3MEN1NPC1RAB9A | |
| SCHEMBL12101200 | 0.82 | ALOX15 (0.77) | F7F3MEN1NPC1RAB9A | |
| SCHEMBL764543 | 0.80 | F7 (0.72) | F7F3MEN1NPC1RAB9A | |
| SCHEMBL7877880 | 0.80 | F7 (0.55) | F7F3MEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7873363 | 0.79 | F7 (0.54) | F7F3MEN1NPC1RAB9A | |
| SCHEMBL2729831 | 0.77 | F7 (0.72) | F7F3MEN1NPC1RAB9A | |
| SCHEMBL3963537 | 0.76 | F7 (0.66) | F7F3MEN1NPC1RAB9A | |
| SCHEMBL3499567 | 0.76 | F7 (0.76) | F7F3MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |