Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | F13A1 | P00488 | 2/20 | 0.52 |
| ▸ | TGM2 | P21980 | 2/20 | 0.52 |
| ▸ | TGM1 | P22735 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13161203 | 0.88 | HSD11B1 (0.72) | HSD11B1SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2514580 | 0.88 | EPHX2 (0.52) | HSD11B1SMN1; SMN2NPC1RAB9ACHRM2 | |
| SCHEMBL5251521 | 0.88 | EPHX2 (0.52) | HSD11B1SMN1; SMN2NPC1RAB9ACHRM2 | |
| SCHEMBL13521537 | 0.87 | MEN1 (0.57) | HSD11B1SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL1191110 | 0.85 | HSD11B1 (0.64) | HSD11B1SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL28649957 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AUSP30CYP2C19 | |
| SCHEMBL6174316 | 0.84 | KDM5A (0.54) | HSD11B1SMN1; SMN2NPC1RAB9AUSP30 | |
| SCHEMBL12745137 | 0.84 | SMN1; SMN2 (0.61) | HSD11B1SMN1; SMN2NPC1RAB9AUSP30 | |
| SCHEMBL31379527 | 0.84 | SMN1; SMN2 (0.61) | HSD11B1SMN1; SMN2NPC1RAB9AUSP30 | |
| SCHEMBL15669761 | 0.84 | SMN1; SMN2 (0.62) | HSD11B1SMN1; SMN2NPC1RAB9AUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0828754-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038471-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |