Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163506 | 0.90 | CCNA2 (0.35) | CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6164167 | 0.88 | CCNA2 (0.38) | CCNA2CDK2RAB9ASMN1; SMN2DHODH | |
| SCHEMBL6163994 | 0.83 | HTT (0.39) | CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6167886 | 0.83 | CCNA2 (0.39) | CCNA2CDK2RAB9ASMN1; SMN2DHODH | |
| SCHEMBL6166346 | 0.83 | CCNA2 (0.39) | CCNA2CDK2RAB9ASMN1; SMN2DHODH | |
| SCHEMBL6164838 | 0.82 | CCNA2 (0.41) | CCNA2CDK2 | |
| SCHEMBL6164260 | 0.82 | ALDH1A1 (0.39) | CCNA2CDK2RAB9ASMN1; SMN2DHODH | |
| SCHEMBL6167945 | 0.81 | DHODH (0.37) | SMN1; SMN2DHODH | |
| SCHEMBL6770749 | 0.81 | SRC (0.35) | SMN1; SMN2DHODH | |
| SCHEMBL6771327 | 0.80 | DHODH (0.32) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |