Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | XIAP | P98170 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353959 | 1.00 | TDP1 (0.64) | TDP1EPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7759004 | 0.99 | TDP1 (0.62) | TDP1EPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6166506 | 0.98 | TDP1 (0.61) | TDP1EPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL20474616 | 0.90 | ALDH1A1 (0.62) | TDP1ALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL18553983 | 0.90 | ALDH1A1 (0.62) | TDP1ALDH1A1KDM4ESMN1; SMN2CYP3A4 | |
| Trifluoromethanesulfonic Acid SCHEMBL8424410 | 0.89 | TDP1 (0.53) | TDP1EPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3006742 | 0.88 | XIAP (0.51) | TDP1ALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL3006748 | 0.88 | XIAP (0.51) | TDP1ALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL3006751 | 0.88 | XIAP (0.51) | TDP1ALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL14417240 | 0.87 | ALPI (0.50) | TDP1ALDH1A1KDM4ESMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101157720-B | Template-fixed peptidomimetics as serine protease inhibitors | POLYPHOR LTD | 2012-04-04 | — | — | CN | disclosed |
| CN-1688600-B | Template-fixed peptidomimetics with antibacterial activity | POLYPHOR LTD | 2010-04-28 | — | — | CN | disclosed |
| CN-101157720-A | Template fixed peptide analogue as serine protease inhibitor | POLLYFEURE CO LTD (CH) | 2008-04-09 | — | — | CN | disclosed |
| CN-101128421-A | Methods and compositions for treating amyloid-related diseases | NEUROCHEM INTERNAT LTD (CH) | 2008-02-20 | — | — | CN | disclosed |
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| CN-1688600-A | Template-fixed peptidomimetics with antibacterial activity | POLYPHOR LTD (CH) | 2005-10-26 | — | — | CN | disclosed |
| CN-1582296-A | Template-fixed peptidomimetics as serine protease inhibitors | POLYPHOR LTD (CH) | 2005-02-16 | — | — | CN | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |