Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166704 | 0.82 | HTT (0.64) | HTTLMNATSHRPLK1CSNK2A1 | |
| SCHEMBL6165467 | 0.81 | ALDH1A1 (0.45) | HTTALPLALDH1A1MAPTKMT2A | |
| SCHEMBL6165167 | 0.80 | HTT (1.00) | HTTALDH1A1LMNATSHRPLK1 | |
| SCHEMBL6163497 | 0.78 | HTT (0.40) | HTTALPLALDH1A1KMT2ANPSR1 | |
| SCHEMBL6167101 | 0.76 | HTT (0.56) | HTT | |
| SCHEMBL6164656 | 0.76 | HTT (0.68) | HTTPLK1CSNK2A1PLK3BUB1 | |
| SCHEMBL6165245 | 0.76 | HTT (0.68) | HTTALDH1A1NPSR1LMNATSHR | |
| SCHEMBL6164449 | 0.76 | HTT (0.38) | HTTALPLALDH1A1KMT2ANPSR1 | |
| SCHEMBL6167721 | 0.75 | HTT (0.48) | HTT | |
| SCHEMBL6168258 | 0.74 | HTT (0.65) | HTTPLK1CSNK2A1PLK3BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |