Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166859 | 0.86 | HTT (0.39) | HTT | |
| SCHEMBL6163497 | 0.84 | HTT (0.40) | HTTALPLALDH1A1KMT2ANPSR1 | |
| SCHEMBL6164374 | 0.83 | ALPL (0.38) | ALPLALDH1A1KMT2ANPSR1 | |
| SCHEMBL6164302 | 0.82 | HTT (0.57) | HTT | |
| SCHEMBL6163627 | 0.81 | HTT (0.40) | HTT | |
| SCHEMBL6166110 | 0.81 | HTT (0.34) | HTT | |
| SCHEMBL6166017 | 0.80 | HTT (0.39) | HTT | |
| SCHEMBL6164044 | 0.79 | HTT (0.39) | HTT | |
| SCHEMBL6164099 | 0.76 | HTT (0.66) | HTTALPLALDH1A1KMT2ANPSR1 | |
| SCHEMBL6165346 | 0.74 | ALDH1A1 (0.40) | ALPLALDH1A1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |