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Sugi Predict / Compounds / Arginine

Arginine

Arginine

SCHEMBL6164492

C[C@@H](O)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)OC(=O)CN.NCC(=O)O

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ OTC P00480 1/20 0.35
▸ DDAH1 O94760 3/20 0.34
▸ NOS1 P29475 3/20 0.34
▸ NOS3 P29474 2/20 0.34
▸ NOS2 P35228 2/20 0.34
▸ NPY4R P50391 7/20 0.33
▸ NPY1R P25929 5/20 0.33
▸ GSR P00390 1/20 0.31
▸ NPY2R P49146 4/20 0.31
▸ NPY5R Q15761 4/20 0.31
▸ MEN1 O00255 1/20 0.30
▸ CYP2C19 P33261 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL2497437 0.94 OTC (0.32) OTCDDAH1NOS1NOS3NOS2
Arginine SCHEMBL2762369 0.90 OTC (0.42) OTCDDAH1NOS1NOS3NOS2
Arginine SCHEMBL4390114 0.88 PRCP (0.31) —
Serine SCHEMBL18223737 0.85 OTC (0.36) OTCDDAH1NOS1NOS3NOS2
Arginine SCHEMBL27842844 0.85 OTC (0.46) OTCDDAH1NOS1NOS3NOS2
Arginine SCHEMBL1965664 0.85 OTC (0.46) OTCDDAH1NOS1NOS3NOS2
Arginine SCHEMBL3898452 0.85 OTC (0.46) OTCDDAH1NOS1NOS3NOS2
Arginine SCHEMBL20996120 0.85 OTC (0.46) OTCDDAH1NOS1NOS3NOS2
Arginine SCHEMBL4394264 0.85 — —
Threonine SCHEMBL285577 0.84 NPY4R (0.36) OTCDDAH1NOS1NOS3NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1504033-A2 CONNECTIVE TISSUE STIMULATING PEPTIDES MILLENIUM BIOLOGIX INC. (CA) 2005-02-09 — — EP claimed
WO-2003093314-A2 CONNECTIVE TISSUE STIMULATING PEPTIDES MILLENIUM BIOLOGIX INC. (CA) 2003-11-13 — — WO claimed
EP-1504033-A2 CONNECTIVE TISSUE STIMULATING PEPTIDES MILLENIUM BIOLOGIX INC. (CA) 2005-02-09 — — EP disclosed
WO-2003093314-A2 CONNECTIVE TISSUE STIMULATING PEPTIDES MILLENIUM BIOLOGIX INC. (CA) 2003-11-13 — — WO disclosed