Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10346039 | 0.81 | IDO1 (0.39) | IDO1PDPK1GID4RECQLHTR2A | |
| SCHEMBL15499549 | 0.71 | CA4 (0.35) | HTR2C | |
| SCHEMBL5749728 | 0.69 | DRD1 (0.35) | IDO1PDPK1GID4HTR2APRCP | |
| SCHEMBL16866691 | 0.69 | HTR2A (0.47) | IDO1PDPK1GID4HTR2ARET | |
| SCHEMBL8212470 | 0.69 | CHRNA7 (0.49) | IDO1PDPK1GID4HTR2ARET | |
| SCHEMBL6112737 | 0.68 | ALDH1A1 (0.41) | CETP | |
| SCHEMBL1804088 | 0.67 | — | — | |
| SCHEMBL21300294 | 0.66 | IDO1 (0.66) | IDO1PDPK1CYP11B2PIN1 | |
| SCHEMBL14209228 | 0.66 | IDO1 (0.66) | IDO1PDPK1CYP11B2PIN1 | |
| SCHEMBL447420 | 0.66 | IDO1 (0.66) | IDO1PDPK1CYP11B2PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558582-B1 | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2005-12-21 | — | — | EP | disclosed |