Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19712313 | 0.67 | EPHX2 (0.40) | EPHX2MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4081806 | 0.66 | TSHR (0.38) | EPHX2SMN1; SMN2ALDH1A1TSHRNPC1 | |
| SCHEMBL2687705 | 0.64 | EPHX2 (0.62) | EPHX2SMN1; SMN2ALDH1A1TSHRNPC1 | |
| SCHEMBL3345536 | 0.64 | HTT (0.41) | ALDH1A1LMNACYP2D6CYP2C19MMP1 | |
| SCHEMBL19712342 | 0.63 | HSD17B10 (0.44) | EPHX2SMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL6162053 | 0.63 | LMNA (0.42) | ALDH1A1LMNACYP2D6CYP2C19MMP1 | |
| SCHEMBL4073041 | 0.62 | ALDH1A1 (0.62) | EPHX2SMN1; SMN2ALDH1A1LMNACYP2D6 | |
| SCHEMBL19712315 | 0.62 | EPHX2 (0.38) | EPHX2MAPTSMN1; SMN2TSHRNPC1 | |
| SCHEMBL295277 | 0.61 | MAOB (0.48) | ALPISMN1; SMN2LMNACYP2C19 | |
| SCHEMBL7749862 | 0.61 | KMT2A (0.46) | ALPLMAPTSMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |