SCHEMBL6164835

SCHEMBL6164835

CCCCc1c[c]ccc1-c1ccccc1-c1nnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.43
AGTR2 P50052 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11045794 0.72 NR1H2 (0.39)
SCHEMBL30743612 0.70 ABCG2 (0.55) AGTR1
SCHEMBL9193828 0.69 AGTR1 (0.64) AGTR1AGTR2
SCHEMBL5454132 0.69 AGTR1 (0.54) AGTR1AGTR2
SCHEMBL1374849 0.69 PSMB5 (0.38)
SCHEMBL5454127 0.68 AGTR1 (0.54) AGTR1AGTR2
SCHEMBL12787571 0.68 AGTR1 (0.54) AGTR1AGTR2
SCHEMBL488980 0.68 AGTR1 (0.50) AGTR1AGTR2
SCHEMBL3407499 0.68 AGTR1 (0.61) AGTR1AGTR2
SCHEMBL4638846 0.67 ABCG2 (0.46) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1546135-A2 NOVEL SYNTHESIS OF IRBESARTAN TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2005-06-29 EP claimed
EP-1509517-A2 NOVEL SYNTHESIS OF IRBESARTAN TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2005-03-02 EP claimed
WO-2004065383-A2 NOVEL SYNTHESIS OF IRBESARTAN TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2004-08-05 WO claimed
WO-2004007482-A2 NOVEL SYNTHESIS OF IRBESARTAN TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2004-01-22 WO claimed