Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | KCNQ4 | P56696 | 4/20 | 0.37 |
| ▸ | KCNQ5 | Q9NR82 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197226 | 0.86 | AAK1 (0.43) | AAK1CYP17A1KCNQ4KCNQ5RXFP1 | |
| SCHEMBL6165321 | 0.85 | AAK1 (0.37) | AAK1RXFP1MAP4K4 | |
| SCHEMBL2320229 | 0.84 | LMNA (0.41) | AAK1KCNQ4KCNQ5RXFP1 | |
| SCHEMBL6166163 | 0.84 | CA12 (0.36) | AAK1RXFP1MAP4K4 | |
| SCHEMBL5562894 | 0.83 | RXFP1 (0.38) | AAK1CYP17A1KCNQ4KCNQ5RXFP1 | |
| SCHEMBL6163360 | 0.81 | AAK1 (0.37) | AAK1CYP17A1KCNQ4KCNQ5RXFP1 | |
| SCHEMBL3568182 | 0.81 | AAK1 (0.40) | AAK1CYP17A1KCNQ4KCNQ5RXFP1 | |
| SCHEMBL6162611 | 0.81 | TRPA1 (0.38) | AAK1KCNQ4KCNQ5TRPA1 | |
| SCHEMBL6607723 | 0.80 | HDAC1 (0.38) | KCNQ4KCNQ5HDAC1HDAC2KCNQ3 | |
| SCHEMBL6165636 | 0.80 | MAPT (0.40) | CYP17A1KCNQ4KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-B1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | HOFFMANN LA ROCHE (CH) | 2005-07-20 | — | — | EP | disclosed |
| US-6544985-B2 | For therapy of acute and/or chronic neurological disorders such as psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits | HOFFMAN-LA ROCHE INC. | 2003-04-08 | — | — | US | disclosed |
| US-20020193367-A1 | Dihydro-benzo [b] [1,4] diazepin-2-one derivatives | F. HOFFMAN-LA ROCHE AG A SWISS COMPANY (CH) | 2002-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193367-A1 | Dihydro-benzo [b] [1,4] diazepin-2-one derivatives | CYP1B1, GRIN2B, BDKRB1 | AAK1 2640/4885CYP17A1 646/4885KCNQ4 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.