Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.68 |
| ▸ | KDR | P35968 | 9/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162952 | 0.92 | KDR (0.70) | EGFRKDRABCG2HDAC3HDAC1 | |
| SCHEMBL6162829 | 0.92 | KDR (0.70) | EGFRKDRABCG2HDAC3HDAC1 | |
| SCHEMBL6165325 | 0.90 | EGFR (0.73) | EGFRKDRABCG2ERBB2ERBB4 | |
| SCHEMBL6165317 | 0.90 | EGFR (0.73) | EGFRKDRABCG2ERBB2ERBB4 | |
| SCHEMBL6164322 | 0.81 | ABCG2 (0.73) | EGFRKDRABCG2HDAC3HDAC1 | |
| SCHEMBL6162864 | 0.81 | ABCG2 (0.73) | EGFRKDRABCG2HDAC3HDAC1 | |
| SCHEMBL3529976 | 0.81 | ABCG2 (0.73) | EGFRKDRABCG2HDAC3HDAC1 | |
| SCHEMBL30891782 | 0.81 | EGFR (0.83) | EGFRKDRERBB2RETLCK | |
| SCHEMBL6686765 | 0.81 | EGFR (0.79) | EGFRKDRERBB2ERBB4AURKB | |
| SCHEMBL6164038 | 0.81 | HDAC1 (0.71) | EGFRKDRABCG2ERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218357-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-04-06 | — | — | EP | claimed |