Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164065 | 0.84 | SMN1; SMN2 (0.44) | CCNA2CDK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6164575 | 0.84 | CCNA2 (0.38) | CCNA2CDK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6163516 | 0.83 | CCNA2 (0.41) | CCNA2CDK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6165619 | 0.82 | CCNA2 (0.37) | CCNA2CDK2RAB9ASMN1; SMN2PARP1 | |
| SCHEMBL6164846 | 0.80 | CCNA2 (0.38) | CCNA2CDK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6165092 | 0.78 | CCNA2 (0.38) | CCNA2CDK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6167319 | 0.77 | RAB9A (0.38) | CCNA2CDK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6164821 | 0.73 | CYP1A2 (0.43) | CCNA2CDK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6165976 | 0.72 | ADORA1 (0.38) | RAB9ASMN1; SMN2ALDH1A1KDM4EALPL | |
| SCHEMBL6167555 | 0.71 | CCNA2 (0.39) | CCNA2CDK2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |