Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167448 | 0.85 | CYP1A2 (0.39) | CYP1A2RAB9ASMN1; SMN2CCNA2CDK2 | |
| SCHEMBL6164065 | 0.81 | SMN1; SMN2 (0.44) | CYP1A2RAB9ASMN1; SMN2CCNA2CDK2 | |
| SCHEMBL6167555 | 0.77 | CCNA2 (0.39) | RAB9ASMN1; SMN2CCNA2CDK2 | |
| SCHEMBL6163500 | 0.74 | CYP1A2 (0.46) | CYP1A2GRM5 | |
| SCHEMBL6163516 | 0.74 | CCNA2 (0.41) | RAB9ASMN1; SMN2CCNA2CDK2KDM4E | |
| SCHEMBL6167319 | 0.74 | RAB9A (0.38) | RAB9ASMN1; SMN2CCNA2CDK2KDM4E | |
| SCHEMBL6164846 | 0.73 | CCNA2 (0.38) | RAB9ASMN1; SMN2CCNA2CDK2ALDH1A1 | |
| SCHEMBL6165092 | 0.71 | CCNA2 (0.38) | RAB9ASMN1; SMN2CCNA2CDK2ALDH1A1 | |
| SCHEMBL6167233 | 0.69 | CDK2 (0.39) | CYP1A2RAB9ASMN1; SMN2CCNA2CDK2 | |
| SCHEMBL6167058 | 0.66 | KDM4E (0.41) | CYP1A2RAB9ASMN1; SMN2CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |