Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847342 | 0.76 | CCR1 (0.53) | DRD2DRD3HTR1ADRD1DRD5 | |
| SCHEMBL5848812 | 0.74 | CCR3 (0.59) | DRD2DRD3HTR1ADRD1DRD5 | |
| SCHEMBL5848148 | 0.74 | CCR3 (0.58) | DRD2 | |
| SCHEMBL5848317 | 0.73 | CCR1 (0.44) | DRD2DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL5847405 | 0.72 | ALDH1A1 (0.58) | DRD2DRD3HTR1ADRD1DRD5 | |
| SCHEMBL6160929 | 0.71 | CCR1 (0.52) | DRD2DRD3HTR1ADRD1DRD5 | |
| SCHEMBL5847140 | 0.71 | OPRL1 (0.56) | DRD2DRD3HTR1ADRD1DRD5 | |
| SCHEMBL10420947 | 0.70 | OPRL1 (0.55) | — | |
| SCHEMBL27508734 | 0.68 | POLB (0.46) | — | |
| SCHEMBL8416478 | 0.65 | DRD2 (0.56) | DRD2DRD3HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721455-B9 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2005-04-20 | — | — | EP | disclosed |
| EP-0721455-B1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2002-12-11 | — | — | EP | disclosed |