Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166699 | 0.83 | HTT (0.61) | HTTCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6166017 | 0.83 | HTT (0.39) | HTTCNR1 | |
| SCHEMBL6166081 | 0.81 | BRD4 (0.34) | CSNK2A2CSNK2BCSNK2A1ABCG2OPRM1 | |
| SCHEMBL6166773 | 0.80 | HTT (0.52) | HTTEPHX2OPRM1 | |
| SCHEMBL6165102 | 0.80 | HTT (0.41) | HTTCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6164263 | 0.80 | HTT (0.41) | HTTCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6163497 | 0.78 | HTT (0.40) | HTTCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6167888 | 0.77 | HTT (0.39) | HTTCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL6168258 | 0.77 | HTT (0.65) | HTTCSNK2A1EPHX2BUB1 | |
| SCHEMBL6164113 | 0.77 | OPRM1 (0.49) | HTTOPRM1BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |