Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168258 | 0.91 | HTT (0.65) | HTTEPHX2 | |
| SCHEMBL6164339 | 0.81 | HTT (0.34) | HTT | |
| SCHEMBL6166391 | 0.80 | HTT (0.42) | HTTEPHX2OPRM1 | |
| SCHEMBL6164113 | 0.79 | OPRM1 (0.49) | HTTOPRM1 | |
| SCHEMBL6166242 | 0.76 | HTT (0.42) | HTT | |
| SCHEMBL6166246 | 0.76 | HTT (0.42) | HTT | |
| SCHEMBL6167721 | 0.74 | HTT (0.48) | HTT | |
| SCHEMBL6164169 | 0.71 | HTT (0.48) | HTT | |
| SCHEMBL6165167 | 0.69 | HTT (1.00) | HTTOPRM1 | |
| SCHEMBL6167339 | 0.68 | HTT (0.45) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |