Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | HCK | P08631 | 13/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162310 | 0.91 | MAPK14 (0.58) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6163672 | 0.91 | MAPK14 (0.53) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6163413 | 0.86 | MAPK14 (0.53) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6163825 | 0.85 | MAPK14 (0.51) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6163117 | 0.82 | RAF1 (0.56) | MAPK14RAF1MAPK12 | |
| SCHEMBL6163294 | 0.81 | MAPK14 (0.61) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6165244 | 0.81 | MAPK14 (0.50) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6162950 | 0.81 | MAPK14 (0.46) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6166487 | 0.80 | MAPK14 (0.60) | MAPK14RAF1HCKMAPK12TNF | |
| SCHEMBL6163420 | 0.79 | MAPK14 (0.51) | MAPK14RAF1HCKMAPK12TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |