Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 11/20 | 0.39 |
| ▸ | BCHE | P06276 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168389 | 0.83 | KDM4E (0.41) | CRHR1KDM4EALDH1A1HPGDACHE | |
| SCHEMBL6167259 | 0.82 | CRHR1 (0.44) | CRHR1KDM4EALDH1A1HPGDACHE | |
| SCHEMBL6165056 | 0.81 | CRHR1 (0.43) | CRHR1KDM4EALDH1A1HPGDACHE | |
| SCHEMBL6172728 | 0.81 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL7481401 | 0.79 | CRHR1 (0.65) | CRHR1ALDH1A1 | |
| SCHEMBL7477860 | 0.78 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL6169156 | 0.76 | KDM4E (0.40) | KDM4EALDH1A1HPGDACHEBCHE | |
| SCHEMBL7480941 | 0.76 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL6169536 | 0.75 | CRHR1 (0.41) | CRHR1KDM4EALDH1A1HPGDACHE | |
| SCHEMBL6166551 | 0.74 | KDM4E (0.43) | CRHR1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499599-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2005-01-26 | — | — | EP | claimed |
| WO-2003091225-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-11-06 | — | — | WO | claimed |
| EP-1499599-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003091225-A1 | SUBSTITUTED PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-11-06 | — | — | WO | disclosed |