Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167532 | 0.93 | EP300 (0.32) | HSD11B1CREBBPEP300 | |
| SCHEMBL6609350 | 0.91 | HSD11B1 (0.36) | HSD11B1CREBBPEP300 | |
| SCHEMBL6165819 | 0.88 | EP300 (0.31) | HSD11B1CREBBPEP300 | |
| SCHEMBL6626793 | 0.87 | EP300 (0.33) | HSD11B1CREBBPEP300 | |
| SCHEMBL6165534 | 0.86 | EP300 (0.32) | HSD11B1CREBBPEP300 | |
| SCHEMBL6165572 | 0.86 | EP300 (0.30) | HSD11B1CREBBPEP300 | |
| SCHEMBL6163327 | 0.86 | HSD11B1 (0.34) | HSD11B1CREBBPEP300 | |
| SCHEMBL6165821 | 0.84 | HSD11B1 (0.33) | HSD11B1CREBBPEP300 | |
| SCHEMBL6165565 | 0.84 | EP300 (0.33) | HSD11B1CREBBPEP300 | |
| SCHEMBL6608546 | 0.83 | HSD11B1 (0.36) | HSD11B1CREBBPEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-B1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | HOFFMANN LA ROCHE (CH) | 2005-07-20 | — | — | EP | disclosed |