Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165821 | 0.93 | HSD11B1 (0.33) | HSD11B1CREBBPEP300 | |
| SCHEMBL6166744 | 0.91 | HSD11B1 (0.34) | HSD11B1CREBBPEP300 | |
| SCHEMBL6608114 | 0.88 | NPY2R (0.35) | HSD11B1CREBBPEP300 | |
| SCHEMBL6626793 | 0.88 | EP300 (0.33) | HSD11B1CREBBPEP300 | |
| SCHEMBL6164841 | 0.88 | EP300 (0.32) | HSD11B1CREBBPEP300 | |
| SCHEMBL6624529 | 0.87 | NPY2R (0.35) | HSD11B1CREBBPEP300 | |
| SCHEMBL6164700 | 0.87 | EP300 (0.32) | HSD11B1CREBBPEP300 | |
| SCHEMBL6165935 | 0.87 | EP300 (0.32) | HSD11B1CREBBPEP300 | |
| SCHEMBL6163327 | 0.87 | HSD11B1 (0.34) | HSD11B1CREBBPEP300 | |
| SCHEMBL6163377 | 0.86 | EP300 (0.32) | HSD11B1CREBBPEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |