Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630659 | 0.84 | TSHR (0.43) | GAAHTTKMT2APOLBEZH2 | |
| SCHEMBL631683 | 0.82 | MEN1 (0.45) | HTTKMT2APOLBEZH2TSHR | |
| SCHEMBL5170755 | 0.74 | TSHR (0.54) | GAAHTTKMT2APOLBEZH2 | |
| SCHEMBL7977721 | 0.72 | POLB (0.45) | GAAHTTKMT2AKDM4EPOLB | |
| SCHEMBL2687705 | 0.69 | EPHX2 (0.62) | KMT2ATSHRMEN1 | |
| SCHEMBL19712313 | 0.69 | EPHX2 (0.40) | TSHRMAPT | |
| SCHEMBL19712342 | 0.68 | HSD17B10 (0.44) | GAAPOLBTSHR | |
| SCHEMBL17067309 | 0.68 | POLB (0.59) | GAAHTTKMT2AKDM4EPOLB | |
| SCHEMBL6166782 | 0.68 | POLB (0.62) | GAAHTTKMT2AKDM4EPOLB | |
| SCHEMBL19712315 | 0.67 | EPHX2 (0.38) | TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |