Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164113 | 0.81 | OPRM1 (0.49) | OPRM1ALPLCRHBPCRHR2HTT | |
| SCHEMBL6162637 | 0.77 | OPRM1 (0.63) | OPRM1HTTKMT2AHSD17B10LMNA | |
| SCHEMBL6166168 | 0.77 | OPRM1 (0.55) | OPRM1HTTKMT2AHSD17B10OPRK1 | |
| SCHEMBL6165826 | 0.74 | HTT (0.41) | OPRM1HTTLMNA | |
| SCHEMBL6770500 | 0.74 | OPRM1 (0.61) | OPRM1OPRK1OPRD1 | |
| SCHEMBL6166935 | 0.73 | OPRM1 (0.39) | OPRM1ALPLCRHBPCRHR2HTT | |
| SCHEMBL6767529 | 0.73 | OPRM1 (0.72) | OPRM1KMT2ALMNAOPRK1OPRD1 | |
| SCHEMBL6165838 | 0.72 | OPRM1 (0.62) | OPRM1OPRK1OPRD1 | |
| SCHEMBL15730601 | 0.72 | OPRM1 (0.54) | OPRM1ALPLCRHBPCRHR2HTT | |
| SCHEMBL6162505 | 0.71 | ALPL (0.67) | OPRM1ALPLCRHBPCRHR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |