Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | GPR174 | Q9BXC1 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611671 | 0.84 | MAPT (0.59) | MAPTMAPK1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6612169 | 0.84 | SERPINE1 (0.48) | MAPTALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6164728 | 0.83 | MAPT (0.54) | MAPTPKMMAPK1ALDH1A1GPR174 | |
| SCHEMBL6609390 | 0.83 | MAPT (0.60) | MAPTPKMMAPK1ALDH1A1LMNA | |
| SCHEMBL31423849 | 0.80 | MAPT (0.63) | MAPTPKMMAPK1ALDH1A1GPR174 | |
| SCHEMBL8103160 | 0.79 | MAPT (0.62) | MAPTALDH1A1GPR174LMNASMN1; SMN2 | |
| SCHEMBL6608182 | 0.78 | TSHR (0.48) | MAPTMAPK1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL8070760 | 0.78 | MAPT (0.50) | MAPTPKMMAPK1ALDH1A1GPR174 | |
| SCHEMBL8073995 | 0.77 | GPR174 (0.54) | MAPTPKMMAPK1ALDH1A1GPR174 | |
| SCHEMBL1067339 | 0.75 | CXCR2 (0.43) | MAPTMAPK1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-B1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | HOFFMANN LA ROCHE (CH) | 2005-07-20 | — | — | EP | disclosed |
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |