SCHEMBL8073995

SCHEMBL8073995

CC(=O)Nc1cc(N2CCC(O)CC2)c(F)cc1[N+](=O)[O-]

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GPR174 Q9BXC1 5/20 0.54
ALDH1A1 P00352 7/20 0.52
MAPT P10636 12/20 0.51
MAPK1 P28482 4/20 0.51
LMNA P02545 3/20 0.48
GAA P10253 1/20 0.48
HTT P42858 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
PKM P14618 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8103160 0.86 MAPT (0.62) GPR174ALDH1A1MAPTLMNAGAA
SCHEMBL8070760 0.85 MAPT (0.50) GPR174ALDH1A1MAPTMAPK1LMNA
SCHEMBL8074358 0.84 GPR174 (0.48) GPR174ALDH1A1MAPTMAPK1LMNA
SCHEMBL8074360 0.82 GPR174 (0.45) GPR174ALDH1A1MAPTMAPK1LMNA
SCHEMBL10990742 0.81 CYP3A4 (0.39) GPR174ALDH1A1MAPTMAPK1GAA
SCHEMBL10996678 0.81 MAPT (0.41) GPR174ALDH1A1MAPTMAPK1GAA
SCHEMBL10995495 0.78 MAPT (0.59) GPR174ALDH1A1MAPTMAPK1LMNA
SCHEMBL30783718 0.77 MAPT (0.61) GPR174ALDH1A1MAPTMAPK1LMNA
SCHEMBL6166846 0.77 MAPT (0.59) GPR174ALDH1A1MAPTMAPK1LMNA
SCHEMBL1425030 0.77 MAPT (0.55) ALDH1A1MAPTLMNAGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6051570-A ANTIULCER AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-04-18 US disclosed
EP-0983263-A1 NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-03-08 EP disclosed
WO-1998054172-A1 NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 1998-12-03 WO disclosed
US-4552879-A BACTERICIDES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1985-11-12 US disclosed
US-4399134-A BACTERICIDES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1983-08-16 US disclosed