Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 9/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166941 | 1.00 | CYP1A1 (0.53) | CYP1A1CYP1A2CYP1B1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL6166154 | 0.99 | CYP1A1 (0.52) | CYP1A1CYP1A2CYP1B1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL6166145 | 0.99 | CYP1A1 (0.52) | CYP1A1CYP1A2CYP1B1ALDH1A1KDM4E | |
| SCHEMBL6166697 | 0.90 | CYP1A1 (0.58) | CYP1A1CYP1A2CYP1B1ALDH1A1KDM4E | |
| SCHEMBL6166690 | 0.90 | CYP1A1 (0.58) | CYP1A1CYP1A2CYP1B1ALDH1A1KDM4E | |
| SCHEMBL7994636 | 0.80 | RAB9A (0.46) | CYP1A1CYP1A2CYP1B1ALDH1A1KDM4E | |
| SCHEMBL7994633 | 0.80 | RAB9A (0.46) | CYP1A1CYP1A2CYP1B1ALDH1A1KDM4E | |
| SCHEMBL6167690 | 0.77 | CYP1A2 (0.53) | CYP1A1CYP1A2CYP1B1KDM4EPOLB | |
| SCHEMBL6167684 | 0.77 | CYP1A2 (0.53) | CYP1A1CYP1A2CYP1B1KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL6167398 | 0.76 | CYP1A2 (0.52) | CYP1A1CYP1A2CYP1B1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187264-A1 | Phosphodiesterase iv inhibitor containing pyridylacrylamide derivative | TSUMURA & CO. (JP) | 2005-08-25 | — | — | US | disclosed |
| EP-1495757-A1 | PHOSPHODIESTERASE IV INHIBITOR CONTAINING PYRIDYLACRYLAMIDE DERIVATIVE | TSUMURA & CO. (JP) | 2005-01-12 | — | — | EP | disclosed |
| US-6313153-B1 | ADMINISTERING PYRIDYLACRYLAMIDE COMPOUND FOR THERAPY OF NEPHRITIS | TSUMURA & CO. (JP) | 2001-11-06 | — | — | US | disclosed |
| EP-1000935-A1 | PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-$g(b) INHIBITORS CONTAINING THE SAME | TSUMURA & CO. (JP) | 2000-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187264-A1 | Phosphodiesterase iv inhibitor containing pyridylacrylamide derivative | PDE3B, PDE3A, PDE2A | CYP1A1 194/4885CYP1A2 125/4885CYP1B1 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.