Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 15/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167230 | 1.00 | CCR5 (0.42) | CCR5KCNH2L3MBTL1LMNACYP2D6 | |
| SCHEMBL4011542 | 0.90 | CCR5 (0.42) | CCR5KCNH2L3MBTL1LMNACYP2D6 | |
| SCHEMBL4011538 | 0.90 | CCR5 (0.42) | CCR5KCNH2L3MBTL1LMNACYP2D6 | |
| SCHEMBL3064218 | 0.81 | CCR5 (0.47) | CCR5KCNH2L3MBTL1LMNACYP2D6 | |
| SCHEMBL3064217 | 0.81 | CCR5 (0.47) | CCR5KCNH2L3MBTL1LMNACYP2D6 | |
| SCHEMBL13834246 | 0.77 | CCR5 (0.40) | CCR5L3MBTL1LMNACYP2D6CYP11B2 | |
| SCHEMBL13834245 | 0.77 | CCR5 (0.40) | CCR5L3MBTL1LMNACYP2D6CYP11B2 | |
| SCHEMBL4134072 | 0.77 | DYRK1A (0.53) | CCR5L3MBTL1LMNACYP2D6 | |
| SCHEMBL4901353 | 0.77 | CYP11B2 (0.38) | CCR5KCNH2CYP2D6CYP11B2AOC3 | |
| SCHEMBL4902112 | 0.77 | CYP11B2 (0.40) | CCR5KCNH2LMNACYP11B2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569646-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004054974-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |