Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 14/20 | 0.79 |
| ▸ | MAOA | P21397 | 13/20 | 0.79 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.74 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.65 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167500 | 1.00 | MAOB (0.79) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL6171245 | 0.97 | MAOB (0.74) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL6171239 | 0.97 | MAOB (0.74) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL29288199 | 0.94 | MAOB (0.78) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL29288203 | 0.94 | MAOB (0.78) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL6167377 | 0.93 | SPHK1 (0.76) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL6167379 | 0.93 | SPHK1 (0.76) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL6508605 | 0.90 | MAOB (0.65) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL6508602 | 0.90 | MAOB (0.65) | MAOBMAOASPHK1SCN3ASPHK2 | |
| SCHEMBL6170997 | 0.89 | MAOB (0.73) | MAOBMAOASPHK1SCN3ASPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | claimed |
| EP-1524265-A1 | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors | Newron Pharmaceuticals S.p.A. (IT) | 2005-04-20 | — | — | EP | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |
| EP-1524265-A1 | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors | Newron Pharmaceuticals S.p.A. (IT) | 2005-04-20 | — | — | EP | disclosed |