Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | NAMPT | P43490 | 4/20 | 0.72 |
| ▸ | MMP13 | P45452 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372128 | 0.88 | TSHR (0.74) | TSHRNAMPTALDH1A1HDAC3HDAC4 | |
| SCHEMBL19358859 | 0.88 | ALDH1A1 (0.84) | TSHRNAMPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3918322 | 0.87 | TSHR (0.76) | TSHRNAMPTALDH1A1HDAC3HDAC4 | |
| SCHEMBL354041 | 0.86 | TSHR (0.76) | TSHRNAMPTHDAC3HDAC4HDAC1 | |
| SCHEMBL19028142 | 0.86 | TSHR (0.76) | TSHRNAMPTMMP13HDAC3HDAC4 | |
| SCHEMBL5078944 | 0.86 | TSHR (0.71) | TSHRNAMPTMMP13ALDH1A1HDAC3 | |
| SCHEMBL13102334 | 0.85 | MMP13 (0.85) | TSHRNAMPTMMP13ALDH1A1SMN1; SMN2 | |
| SCHEMBL29437161 | 0.85 | MMP13 (0.85) | TSHRNAMPTMMP13ALDH1A1SMN1; SMN2 | |
| SCHEMBL28793879 | 0.85 | TSHR (0.74) | TSHRNAMPTHDAC3HDAC4HDAC1 | |
| Iodide SCHEMBL15903217 | 0.85 | TSHR (0.74) | TSHRNAMPTHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537085-A1 | OXYTOCIN INHIBITORS | Pfizer Limited (GB) | 2005-06-08 | — | — | EP | claimed |
| WO-2004020414-A1 | OXYTOCIN INHIBITORS | PFIZER LIMITED (GB) | 2004-03-11 | — | — | WO | claimed |
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | disclosed |