SCHEMBL6167802

SCHEMBL6167802

[c]1nc(Cc2cccnc2)cs1

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2D6 P10635 2/20 0.42
CHRNB2 P17787 3/20 0.41
CHRNA4 P43681 3/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CHRNA7 P36544 1/20 0.41
MMP2 P08253 1/20 0.41
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
TBXAS1 P24557 2/20 0.39
CYP2A6 P11509 1/20 0.39
NAPRT Q6XQN6 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6163991 0.79 CYP17A1 (0.40) HRH4HRH3CYP1A2CYP2D6L3MBTL1
SCHEMBL727185 0.73 CYP1A2 (0.62) HRH4HRH3CYP1A2CYP2D6CHRNB2
SCHEMBL6166150 0.70 HRH4 (0.42) HRH4HRH3CYP1A2CYP2D6CHRNB2
SCHEMBL6168635 0.70 HRH4 (0.46) HRH4HRH3CYP1A2CYP2D6CHRNB2
SCHEMBL6164175 0.69 L3MBTL1 (0.42) HRH4HRH3TDP1L3MBTL1
SCHEMBL2749985 0.68 CYP1A2 (0.71) HRH4HRH3CYP1A2CYP2D6CHRNB2
SCHEMBL14257669 0.68 CYP1A2 (0.56) HRH4HRH3CYP1A2CYP2D6CHRNB2
SCHEMBL177863 0.68 CYP11B1 (0.65) HRH4HRH3CYP1A2CYP2D6CHRNA7
SCHEMBL29995759 0.68 CYP11B1 (0.65) HRH4HRH3CYP1A2CYP2D6CHRNA7
SCHEMBL24768055 0.67 CYP2A6 (0.50) HRH4HRH3CYP1A2CYP2D6CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1417177-A4 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS BRISTOL MYERS SQUIBB PHARMA CO (US) 2005-10-19 EP disclosed
EP-1417177-A2 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS Bristol-Myers Squibb Pharma Company (US) 2004-05-12 EP disclosed
WO-2003007883-A2 ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2003-01-30 WO disclosed
EP-1071668-A1 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS Du Pont Pharmaceuticals Company (US) 2001-01-31 EP disclosed
WO-1999054308-A1 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS DU PONT PHARMACEUTICALS COMPANY (US) 1999-10-28 WO disclosed