SCHEMBL6168248

SCHEMBL6168248

COC(=O)c1nc(-c2nccs2)cc(Cl)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 3/20 0.45
CYP1A2 P05177 3/20 0.45
CYP1B1 Q16678 3/20 0.45
HSP90B1 P14625 3/20 0.42
TACR3 P29371 1/20 0.40
SMPD3 Q9NY59 1/20 0.40
HPGD P15428 2/20 0.39
SYK P43405 2/20 0.39
SRC P12931 1/20 0.38
ZAP70 P43403 1/20 0.38
ADORA2A P29274 2/20 0.37
ECE1 P42892 1/20 0.37
HSP90AA1 P07900 2/20 0.37
KCNMA1 Q12791 1/20 0.37
AGER Q15109 1/20 0.37
ADORA1 P30542 1/20 0.36
KDM6B O15054 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2470760 0.87 HPGD (0.42) CYP1A1CYP1A2CYP1B1HSP90B1TACR3
SCHEMBL3328010 0.84 AGER (0.45) CYP1A1CYP1A2CYP1B1HSP90B1TACR3
SCHEMBL6615195 0.83 CYP1A1 (0.46) CYP1A1CYP1A2CYP1B1TACR3SMPD3
SCHEMBL6167281 0.77 KDM4E (0.37)
SCHEMBL320331 0.75 HSP90AA1 (0.47) TACR3HPGDSYKSRCZAP70
SCHEMBL2465851 0.73 ECE1 (0.42) CYP1A1CYP1A2CYP1B1HSP90B1SMPD3
SCHEMBL24984991 0.72 MAPT (0.52)
SCHEMBL2133062 0.72 NPSR1 (0.48)
SCHEMBL2470409 0.70 HSP90AA1 (0.41) CYP1A1CYP1A2CYP1B1TACR3HPGD
SCHEMBL6666990 0.70 ERCC1 (0.66)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT CYP1A1 545/4885CYP1A2 397/4885CYP1B1 318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.