Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.82 |
| ▸ | NPC1 | O15118 | 2/20 | 0.82 |
| ▸ | RAB9A | P51151 | 2/20 | 0.82 |
| ▸ | F7 | P08709 | 1/20 | 0.68 |
| ▸ | F3 | P13726 | 1/20 | 0.68 |
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168943 | 0.88 | MEN1 (0.65) | MEN1KMT2ANPC1RAB9AF7 | |
| SCHEMBL6169285 | 0.88 | RAB9A (0.65) | MEN1KMT2ANPC1RAB9AF7 | |
| SCHEMBL6170035 | 0.87 | MEN1 (0.63) | MEN1KMT2ANPC1RAB9AF7 | |
| SCHEMBL6170838 | 0.86 | MEN1 (0.81) | MEN1KMT2ANPC1RAB9AF7 | |
| SCHEMBL6168456 | 0.85 | MEN1 (0.70) | MEN1KMT2ANPC1RAB9AFLT3 | |
| SCHEMBL17927587 | 0.84 | NPC1 (0.64) | MEN1KMT2ANPC1RAB9AF7 | |
| SCHEMBL6389802 | 0.84 | FLT3 (0.80) | MEN1KMT2ANPC1RAB9AFLT3 | |
| SCHEMBL6405713 | 0.81 | MAPT (0.70) | MEN1KMT2ANPC1RAB9AF7 | |
| SCHEMBL6172296 | 0.81 | MEN1 (0.72) | MEN1KMT2ANPC1RAB9AF7 | |
| SCHEMBL2694131 | 0.81 | F7 (0.74) | MEN1KMT2ANPC1RAB9AF7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |