Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | F7 | P08709 | 1/20 | 0.56 |
| ▸ | F3 | P13726 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170060 | 0.89 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9ACLK1 | |
| SCHEMBL6170838 | 0.89 | MEN1 (0.81) | MEN1KMT2ANPC1RAB9ACLK1 | |
| SCHEMBL6407379 | 0.85 | BCAT1 (0.67) | MEN1KMT2ANPC1RAB9ABCAT1 | |
| SCHEMBL10227495 | 0.83 | PDGFRB (0.68) | MEN1KMT2ANPC1RAB9ACLK1 | |
| SCHEMBL6169285 | 0.82 | RAB9A (0.65) | MEN1KMT2ANPC1RAB9AFLT3 | |
| SCHEMBL6171445 | 0.82 | MEN1 (0.76) | MEN1KMT2ANPC1RAB9AFLT3 | |
| SCHEMBL6168411 | 0.81 | MEN1 (0.82) | MEN1KMT2ANPC1RAB9ACLK1 | |
| SCHEMBL6403700 | 0.81 | BCAT1 (0.62) | MEN1KMT2ANPC1RAB9ABCAT1 | |
| SCHEMBL6173193 | 0.78 | MEN1 (0.64) | MEN1KMT2ANPC1RAB9ACLK1 | |
| SCHEMBL6172428 | 0.77 | MEN1 (0.62) | MEN1KMT2ANPC1RAB9ACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| CN-1284064-A | 2,3-substituted indole compounds as cox-2 inhibitors | PFIZER PHARMA (US) | 2001-02-14 | — | — | CN | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |