Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 8/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173199 | 0.94 | MAPT (0.47) | MAPTTRPV1PPARGPPARACYP2C9 | |
| SCHEMBL6171552 | 0.88 | PTGS2 (0.44) | MAPTTRPV1PPARGPPARACYP2C9 | |
| SCHEMBL6172928 | 0.87 | HPGD (0.47) | MAPTPTGS2PTGS1MEN1ABCC4 | |
| SCHEMBL6172333 | 0.84 | MEN1 (0.44) | MAPTCYP2C9EGFRPTGS2PTGS1 | |
| SCHEMBL6170865 | 0.83 | MAP2 (0.52) | MAPTPTGS2PTGS1MEN1ABCC4 | |
| SCHEMBL6171246 | 0.82 | PTGS2 (0.47) | MAPTPTGS2PTGS1MEN1ABCC4 | |
| SCHEMBL6171881 | 0.81 | KIF11 (0.46) | MAPTPTGS2PTGS1MEN1ABCC4 | |
| SCHEMBL6173940 | 0.81 | CNR1 (0.46) | MAPTCYP2C9PTGS2PTGS1MEN1 | |
| SCHEMBL6171993 | 0.81 | PTGS2 (0.52) | MAPTPTGS2PTGS1MEN1ABCC4 | |
| SCHEMBL6171620 | 0.80 | MAPT (0.47) | MAPTTRPV1PTGS2PTGS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |