Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.41 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.41 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30367555 | 0.81 | TYK2 (0.50) | TYK2SMN1; SMN2TSHRGAAPOLB | |
| SCHEMBL4814573 | 0.81 | TYK2 (0.50) | TYK2SMN1; SMN2TSHRGAAPOLB | |
| SCHEMBL8466158 | 0.75 | SMN1; SMN2 (0.51) | TYK2SMN1; SMN2TSHRGAAPOLB | |
| SCHEMBL30174282 | 0.74 | TSHR (0.41) | TYK2SMN1; SMN2TSHRGAAPOLB | |
| SCHEMBL15491426 | 0.73 | ALDH1A1 (0.54) | TYK2SMN1; SMN2TSHRGAAPOLB | |
| SCHEMBL6531023 | 0.73 | KMT2A (0.43) | NOTUMSMN1; SMN2TSHRGAAALDH1A1 | |
| SCHEMBL4682760 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHRGAAPOLBPDCD1 | |
| SCHEMBL15491451 | 0.72 | TSHR (0.46) | NOTUMTYK2SMN1; SMN2TSHRGAA | |
| SCHEMBL30174254 | 0.72 | TSHR (0.46) | SMN1; SMN2TSHRGAAPOLBKDM4E | |
| SCHEMBL15506087 | 0.72 | GAA (0.41) | TYK2TSHRGAAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448196-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | claimed |
| US-6599901-B1 | Adenosine receptor ligands used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease | HOFFMAN-LA ROCHE INC. | 2003-07-29 | — | — | US | claimed |
| EP-1448196-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | disclosed |
| US-6599901-B1 | Adenosine receptor ligands used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease | HOFFMAN-LA ROCHE INC. | 2003-07-29 | — | — | US | disclosed |