Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.71 |
| ▸ | GCK | P35557 | 2/20 | 0.56 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171043 | 1.00 | PTGS2 (0.71) | PTGS2PTGS1GCKSCN10AIDO1 | |
| SCHEMBL6169595 | 0.99 | PTGS2 (0.73) | PTGS2PTGS1GCKSCN10AIDO1 | |
| SCHEMBL6171148 | 0.89 | PTGS2 (0.69) | PTGS2PTGS1GCKIDO1 | |
| SCHEMBL6170358 | 0.89 | PTGS2 (0.63) | PTGS2PTGS1GCKIDO1 | |
| SCHEMBL6168409 | 0.89 | PTGS2 (0.63) | PTGS2PTGS1GCKSCN10AIDO1 | |
| SCHEMBL6170155 | 0.89 | PTGS2 (0.63) | PTGS2PTGS1GCKSCN10AIDO1 | |
| SCHEMBL6169315 | 0.88 | PTGS2 (0.57) | PTGS2PTGS1GCKSCN10A | |
| SCHEMBL6168649 | 0.88 | PTGS2 (0.62) | PTGS2PTGS1GCKSCN10AIDO1 | |
| SCHEMBL6168388 | 0.87 | PTGS2 (0.65) | PTGS2PTGS1GCKSCN10AIDO1 | |
| SCHEMBL6172202 | 0.87 | PTGS2 (0.69) | PTGS2PTGS1GCKSCN10AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015431-B1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2005-04-20 | — | — | EP | claimed |
| EP-1015431-A1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | Merck Frosst Canada & Co. (CA) | 2000-07-05 | — | — | EP | claimed |
| WO-1999014195-A1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA & CO. (CA) | 1999-03-25 | — | — | WO | claimed |
| EP-1015431-B1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 2005-04-20 | — | — | EP | disclosed |
| EP-1015431-A1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | Merck Frosst Canada & Co. (CA) | 2000-07-05 | — | — | EP | disclosed |
| US-6004950-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; ANALGESIC, ANTIPYRETICS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA, INC. (CA) | 1999-12-21 | — | — | US | disclosed |
| WO-1999014195-A1 | 2-AMINOPYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA & CO. (CA) | 1999-03-25 | — | — | WO | disclosed |